Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size:  2 Capsules
Amount Per Serving
%DV
Vitamin D* (as D3)
25 mcg (1,000 IU)
125%
Women's Probiotic BlendLactobacillus plantarumLactobacillus acidophilusLactobacillus paracaseiLactobacillus rhamnosusLactobacillus gasseriLactobacillus caseiLactobacillus acidophilus NCFM®Lactobacillus reuteriLactobacillus brevisLactobacillus bulgaricusLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
164 mg
+
Total Probiotic Cultures
50 Billion CFU¹
 
Organic Pacran® Whole Cranberry (fruit)
500 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
439 mg
+

Top Medical Research Studies

We explored the relationship between vitamin D (VD) supplementation and the risk of ear infections, specifically in children who frequently suffer from acute otitis media (AOM). The study involved 116 children with a history of recurrent ear infections, who were randomly assigned to receive either a daily dose of 1000 IU of vitamin D or a placebo for four months. Their number of AOM episodes was monitored for six months after the treatment period.

Our findings were quite revealing: the children who received vitamin D supplements had a significantly lower incidence of AOM compared to those who were given the placebo. Specifically, only 26 children in the vitamin D group experienced at least one episode of AOM, versus 38 in the placebo group—a notable difference that became even more pronounced when looking specifically at uncomplicated AOM cases.

We concluded that vitamin D deficiency is common among children who frequently experience ear infections. By restoring serum vitamin D levels to above 30 ng/mL through supplementation, we observed a significant reduction in the risk of uncomplicated AOM. This suggests that vitamin D could play a beneficial role in managing ear infections in children prone to these issues.
Read More
9
Vitamin D's role in ear infections
We investigated how vitamin D levels affect the occurrence of ear infections, specifically in children aged 2 to 7. By looking at data from a pediatric clinic in northwest Romania, we enrolled 118 children—87 with recent ear infections and 31 who hadn't experienced any episodes. This allowed us to compare vitamin D levels across different types of ear infections, like Acute Suppurative Otitis Media and Serous Otitis Media.

Our findings revealed that children suffering from these infections had notably lower vitamin D levels compared to the control group. The children with Acute Suppurative Otitis Media showed the most significant deficiencies. We found a clear link: as vitamin D levels decreased, the frequency of ear infections increased. Logistic regression pointed out that vitamin D insufficiency boosted the odds of ear infections significantly, while Poisson regression established a strong correlation between low vitamin D status and the incidence of these infections.

Overall, these results indicate that low serum vitamin D may play a critical role in the risk of developing ear infections in young children. This suggests that screening and potentially supplementing vitamin D could be valuable strategies for reducing the frequency of ear infections and their associated complications. By addressing this modifiable risk factor, we can help improve the health and quality of life for many children.
Read More
9
Vitamin D enhances tympanoplasty outcomes
We explored how vitamin D (VD) levels influence the outcomes for patients undergoing Type 1 tympanoplasty (T1T), which is a common surgery for chronic ear infections. In our study, we divided 101 patients into four groups based on their VD levels, ranging from severe insufficiency to optimal levels.

Over a 12-month follow-up, we observed that patients with optimal VD levels had significantly higher graft success rates and greater improvements in hearing. Additionally, these patients experienced fewer postoperative infections.

Our findings highlight the importance of monitoring vitamin D levels in patients with chronic ear issues. We believe that addressing VD deficiency could enhance the success of tympanoplasty, suggesting that vitamin D replacement therapy might be beneficial for those with low preoperative levels.
Read More

Most Useful Reviews

9
Immediate relief
177 people found this helpful
After just one day of my mum taking this probiotic, she felt an improvement for her chronic bladder inflammation, causing her pain. She used to have recurring UTIs and now feels relief, which is encouraging for her ongoing treatment. This product is highly recommended!
Read More
9
Chronic infections resolved
10 people found this helpful
This product is phenomenal! I had chronic urinary tract infections for 15 years, including six infections last year alone. Since taking this supplement, I haven’t had any infections, which has left my doctor amazed.
Read More
10
No more UTIs
9 people found this helpful
I bought this product for my daughter, who has struggled with UTI infections since she had a C-section. Since she started using it, she hasn't had a UTI in a year. It's been a remarkable change!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
  • All Researches
9
Vitamin D's role in ear infections
We investigated how vitamin D levels affect the occurrence of ear infections, specifically in children aged 2 to 7. By looking at data from a pediatric clinic in northwest Romania, we enrolled 118 children—87 with recent ear infections and 31 who hadn't experienced any episodes. This allowed us to compare vitamin D levels across different types of ear infections, like Acute Suppurative Otitis Media and Serous Otitis Media.

Our findings revealed that children suffering from these infections had notably lower vitamin D levels compared to the control group. The children with Acute Suppurative Otitis Media showed the most significant deficiencies. We found a clear link: as vitamin D levels decreased, the frequency of ear infections increased. Logistic regression pointed out that vitamin D insufficiency boosted the odds of ear infections significantly, while Poisson regression established a strong correlation between low vitamin D status and the incidence of these infections.

Overall, these results indicate that low serum vitamin D may play a critical role in the risk of developing ear infections in young children. This suggests that screening and potentially supplementing vitamin D could be valuable strategies for reducing the frequency of ear infections and their associated complications. By addressing this modifiable risk factor, we can help improve the health and quality of life for many children.
Read More
9
Vitamin D enhances tympanoplasty outcomes
We explored how vitamin D (VD) levels influence the outcomes for patients undergoing Type 1 tympanoplasty (T1T), which is a common surgery for chronic ear infections. In our study, we divided 101 patients into four groups based on their VD levels, ranging from severe insufficiency to optimal levels.

Over a 12-month follow-up, we observed that patients with optimal VD levels had significantly higher graft success rates and greater improvements in hearing. Additionally, these patients experienced fewer postoperative infections.

Our findings highlight the importance of monitoring vitamin D levels in patients with chronic ear issues. We believe that addressing VD deficiency could enhance the success of tympanoplasty, suggesting that vitamin D replacement therapy might be beneficial for those with low preoperative levels.
Read More
8
Vitamin D levels linked to cholesteatoma
We conducted a study to explore the relationship between vitamin D levels and ear cholesteatoma, a type of middle ear infection. Our research included 62 patients diagnosed with cholesteatoma and compared them with a control group of 62 patients with simple chronic otitis media. Both groups were similar in age and gender, which allowed us to focus solely on the differences in vitamin D levels.

After analyzing the data, we found that vitamin D levels were significantly lower in patients with cholesteatoma compared to those in the control group. This suggests that there might be a connection between low vitamin D levels and the development of cholesteatoma. Furthermore, we noticed that lower vitamin D levels were associated with increased symptoms like hearing loss, tinnitus, and vertigo.

While our findings indicate that vitamin D deficiency could be linked to ear cholesteatoma, we did not evaluate the direct effects of vitamin D treatment on ear infections. Therefore, while vitamin D appears to play a role in this condition, more research is needed to determine whether supplementation might help with symptoms or improve outcomes in patients suffering from cholesteatoma.
Read More
8
Vitamin D may reduce ear infections
We explored the connection between vitamin D levels and chronic otitis media with effusion (COME) in children. In a well-structured case-control study, we analyzed serum 25(OH)D concentrations in 178 children who were referred for tympanostomy tube placement due to COME, compared to 179 healthy children. Our subjects, aged three and four, were recruited from Auckland, New Zealand, and data was collected from May 2011 to November 2013.

Our findings revealed that higher serum 25(OH)D levels were associated with a lower risk of COME. Specifically, with each 10 nmol/L increase in vitamin D levels, the odds of developing COME decreased significantly, even after adjusting for various factors such as age, sex, and breastfeeding duration. This indicates that vitamin D may play a protective role against this type of ear infection.

These results encourage further investigation into whether increasing vitamin D levels—through sun exposure, dietary changes, or supplements—could effectively reduce the risk of ear infections in children. It highlights an area of vitamin D's potential benefits that warrants additional exploration.
Read More
We explored the relationship between vitamin D (VD) supplementation and the risk of ear infections, specifically in children who frequently suffer from acute otitis media (AOM). The study involved 116 children with a history of recurrent ear infections, who were randomly assigned to receive either a daily dose of 1000 IU of vitamin D or a placebo for four months. Their number of AOM episodes was monitored for six months after the treatment period.

Our findings were quite revealing: the children who received vitamin D supplements had a significantly lower incidence of AOM compared to those who were given the placebo. Specifically, only 26 children in the vitamin D group experienced at least one episode of AOM, versus 38 in the placebo group—a notable difference that became even more pronounced when looking specifically at uncomplicated AOM cases.

We concluded that vitamin D deficiency is common among children who frequently experience ear infections. By restoring serum vitamin D levels to above 30 ng/mL through supplementation, we observed a significant reduction in the risk of uncomplicated AOM. This suggests that vitamin D could play a beneficial role in managing ear infections in children prone to these issues.
Read More

User Reviews

USERS' SCORE
Good
Based on 6 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Immediate relief
177 people found this helpful
After just one day of my mum taking this probiotic, she felt an improvement for her chronic bladder inflammation, causing her pain. She used to have recurring UTIs and now feels relief, which is encouraging for her ongoing treatment. This product is highly recommended!
Read More
9
Chronic infections resolved
10 people found this helpful
This product is phenomenal! I had chronic urinary tract infections for 15 years, including six infections last year alone. Since taking this supplement, I haven’t had any infections, which has left my doctor amazed.
Read More
10
No more UTIs
9 people found this helpful
I bought this product for my daughter, who has struggled with UTI infections since she had a C-section. Since she started using it, she hasn't had a UTI in a year. It's been a remarkable change!
Read More
10
Probiotics work better
9 people found this helpful
This product is a must-try for bladder infections! After suffering with chronic bladder infections for over 15 years and consulting numerous doctors, I found probiotics to be far more effective than antibiotics. It truly works!
Read More
10
Free of infections
4 people found this helpful
Highly recommend this product! My mother, in her eighties, dealt with recurrent urinary tract infections and gut health issues. After using the product, she has been free from urinary infections for nearly a year, and her gut health has also improved.
Read More

Frequently Asked Questions

We explored the relationship between vitamin D (VD) supplementation and the risk of ear infections, specifically in children who frequently suffer from acute otitis media (AOM). The study involved 116 children with a history of recurrent ear infections, who were randomly assigned to receive either a daily dose of 1000 IU of vitamin D or a placebo for four months. Their number of AOM episodes was monitored for six months after the treatment period.

Our findings were quite revealing: the children who received vitamin D supplements had a significantly lower incidence of AOM compared to those who were given the placebo. Specifically, only 26 children in the vitamin D group experienced at least one episode of AOM, versus 38 in the placebo group—a notable difference that became even more pronounced when looking specifically at uncomplicated AOM cases.

We concluded that vitamin D deficiency is common among children who frequently experience ear infections. By restoring serum vitamin D levels to above 30 ng/mL through supplementation, we observed a significant reduction in the risk of uncomplicated AOM. This suggests that vitamin D could play a beneficial role in managing ear infections in children prone to these issues.
9
Vitamin D's role in ear infections
We investigated how vitamin D levels affect the occurrence of ear infections, specifically in children aged 2 to 7. By looking at data from a pediatric clinic in northwest Romania, we enrolled 118 children—87 with recent ear infections and 31 who hadn't experienced any episodes. This allowed us to compare vitamin D levels across different types of ear infections, like Acute Suppurative Otitis Media and Serous Otitis Media.

Our findings revealed that children suffering from these infections had notably lower vitamin D levels compared to the control group. The children with Acute Suppurative Otitis Media showed the most significant deficiencies. We found a clear link: as vitamin D levels decreased, the frequency of ear infections increased. Logistic regression pointed out that vitamin D insufficiency boosted the odds of ear infections significantly, while Poisson regression established a strong correlation between low vitamin D status and the incidence of these infections.

Overall, these results indicate that low serum vitamin D may play a critical role in the risk of developing ear infections in young children. This suggests that screening and potentially supplementing vitamin D could be valuable strategies for reducing the frequency of ear infections and their associated complications. By addressing this modifiable risk factor, we can help improve the health and quality of life for many children.
8
Vitamin D may reduce ear infections
We explored the connection between vitamin D levels and chronic otitis media with effusion (COME) in children. In a well-structured case-control study, we analyzed serum 25(OH)D concentrations in 178 children who were referred for tympanostomy tube placement due to COME, compared to 179 healthy children. Our subjects, aged three and four, were recruited from Auckland, New Zealand, and data was collected from May 2011 to November 2013.

Our findings revealed that higher serum 25(OH)D levels were associated with a lower risk of COME. Specifically, with each 10 nmol/L increase in vitamin D levels, the odds of developing COME decreased significantly, even after adjusting for various factors such as age, sex, and breastfeeding duration. This indicates that vitamin D may play a protective role against this type of ear infection.

These results encourage further investigation into whether increasing vitamin D levels—through sun exposure, dietary changes, or supplements—could effectively reduce the risk of ear infections in children. It highlights an area of vitamin D's potential benefits that warrants additional exploration.
7
Vitamin D's Impact on Ear Health
We conducted a study to investigate whether there is a link between Vitamin D deficiency and acute otitis media, which is a common ear infection in children. The research took place at the Paediatric Department of Ataturk University in Turkey and included 169 children; some were diagnosed with ear infections, while others were healthy controls.

Our findings showed that the children suffering from acute otitis media had lower Vitamin D levels compared to their healthy counterparts. Specifically, the average serum 25-hydroxy Vitamin D levels in the children with ear infections were around 20.6 ng/mL, while the controls had about 23.8 ng/mL. Though we didn't see significant differences in calcium and parathormone levels between the groups, the notable drop in Vitamin D levels in those with ear infections suggests that this vitamin may play a role in preventing such infections.

Although this study highlights the potential importance of maintaining adequate Vitamin D levels for children's ear health, it’s essential to remember that it does not definitively prove that Vitamin D treatment can prevent or treat ear infections. Further research is necessary to understand this relationship fully and to explore how Vitamin D supplementation could impact ear infection occurrences.
4
Vitamin D's limited impact on ear infections
We examined the connection between vitamin D levels and ear infections, specifically otitis media (OM). In our analysis, we reviewed studies up until August 2015, focusing on how serum vitamin D levels could influence the risk of developing OM.

Our findings indicated that participants with OM often had lower vitamin D levels compared to those without the condition. Specifically, we noted a marked difference of about -5.67 in vitamin D levels, suggesting that lower levels are linked to the presence of acute OM.

However, when we looked at whether vitamin D levels could actually predict the risk of OM, the results were less encouraging. There was no significant association found; the odds ratio was 0.80, indicating that vitamin D levels did not appear to influence the likelihood of developing OM.

Notably, our analysis suggested that while vitamin D may affect the progression of acute ear infections, it didn't show a significant impact on chronic cases. Overall, while the relationship between vitamin D and ear infections is intriguing, we should be cautious interpreting these findings as a straightforward case for vitamin D treatment.

References

  1. Manole A, Mărcuț LF, Cârciumaru R, Manole F. Preventing Recurrent Otitis Media in Children Aged 2-7 Years: A Cross-Sectional Evaluation of Serum Vitamin D as a Modifiable Factor. Diagnostics (Basel). 2025;15. 10.3390/diagnostics15050519
  2. Kelleş M, Guler Y, Guler R. Vitamin D: A Factor affecting the Success of Type 1 Tympanoplasty. Ear Nose Throat J. 2022. 10.1177/01455613221137224
  3. Fanimolky F, Amizadeh M. Investigation of the Serum Level of Vitamin D in Patients with Ear Cholesteatoma. Iran J Otorhinolaryngol. 2022;34:89. 10.22038/IJORL.2021.52513.2793
  4. Kim HB, Lim SH, Cho CG, Choi HS. Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats. Endocrinol Metab (Seoul). 2018;33:296. 10.3803/EnM.2018.33.2.296
  5. Akcan FA, Dündar Y, Akcan HB, Uluat A, Cebeci D, et al. Clinical role of vitamin D in prognosis of otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2018;105:1. 10.1016/j.ijporl.2017.11.030
  6. Walker RE, Bartley J, Camargo CA, Flint D, Thompson JMD, et al. Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study. Acta Paediatr. 2017;106:1487. 10.1111/apa.13908
  7. Li HB, Tai XH, Sang YH, Jia JP, Xu ZM, et al. Association between vitamin D and development of otitis media: A PRISMA-compliant meta-analysis and systematic review. Medicine (Baltimore). 2016;95:e4739. 10.1097/MD.0000000000004739
  8. Cayir A, Turan MI, Ozkan O, Cayir Y. Vitamin D levels in children diagnosed with acute otitis media. J Pak Med Assoc. 2014;64:1274.
  9. Marchisio P, Consonni D, Baggi E, Zampiero A, Bianchini S, et al. Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children. Pediatr Infect Dis J. 2013;32:1055. 10.1097/INF.0b013e31829be0b0
  10. Cayir A, Turan MI, Ozkan O, Cayir Y, Kaya A, et al. Serum vitamin D levels in children with recurrent otitis media. Eur Arch Otorhinolaryngol. 2014;271:689. 10.1007/s00405-013-2455-7
image